Eggert W, Bernardino L, de Cruz M, Eggert S, Schmidt G
Klinik und Poliklinik für Kinderheilkunde, Humboldt-Universität zu Berlin.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(6):866-73.
In 819 children the Hb concentration, its dependence on the course of disease, the impact of various crises on Hb values and the behaviour of MCHC were evaluated. In the mean there was an anemia of 4.65 +/- 0.5 Hb mmol/l. In the course of 6 years a significant decline anemia of 4.65 +/- 0.5 Hb mmol/l. In the course of 6 years a significant decline of the Hb concentration could be observed. Only those crises connected with severe clinical symptoms (third degree) coincide with a significant Hb decrease. Every second child with a mean Hb value of 2.3 mml/l was transfused. In nearly half the cases there is a normochromic anemia, in 45.7% a hypochromic one. The mean serum bilirubin concentration lay at 31.6 mumol/l and increased with growing age of disease. The anemia has negative effects on the cardio-circulating system. The thorax-heart quotient shows a positive correlation to the degree of anemia.
对819名儿童的血红蛋白浓度、其与病程的关系、各种危象对血红蛋白值的影响以及平均红细胞血红蛋白浓度（MCHC）的变化情况进行了评估。平均血红蛋白浓度为4.65±0.5毫摩尔/升，存在贫血。在6年的病程中，可观察到血红蛋白浓度显著下降。只有那些伴有严重临床症状（三级）的危象才会导致血红蛋白显著降低。平均血红蛋白值为2.3毫摩尔/升的儿童中有一半接受了输血。近一半病例为正色素性贫血，45.7%为低色素性贫血。血清胆红素平均浓度为31.6微摩尔/升，并随病程延长而升高。贫血对心血管循环系统有负面影响。心胸比值与贫血程度呈正相关。
