Foo H, Norgren R
Department of Neural & Behavioral Sciences, College of Medicine, Pennsylvania State University, United States.
Department of Neural & Behavioral Sciences, College of Medicine, Pennsylvania State University, United States.
Physiol Behav. 2014 Apr 10;128:166-71. doi: 10.1016/j.physbeh.2014.02.018. Epub 2014 Feb 15.
Previous studies indicate a role for the glossopharyngeal nerve (GL) in the detection of dietary fats. The present experiments examined the effects of bilateral glossopharyngeal nerve transections (GLx) on the intake of low (4.8%), moderate (16%), and full-fat (100%) corn oil in non-deprived, food-deprived, and water-deprived rats. The rats had access to oils, 0.3 M sucrose, and water in a gustometer that measured number of licks and latency to the first lick during brief access trials. The behavioral measures were used as indices of the amount consumed and the motivation to ingest, respectively. After baseline intakes had stabilized, the rats received GLx or sham transections (Sham) and were then re-tested. Pre and post-surgery responses were compared to determine the impact of GLx on intake and the motivation to ingest. In non-deprived rats, GLx reduced the intake of 4.8% and 16% oils and decreased the motivation to ingest these oils. In food-deprived rats, GLx prevented increases in the ingestion of 4.8% and 16% oils and in the motivation to ingest these oils. In water-deprived rats, GLx reduced the intake of 100% oil and produced a general decrease in the motivation to consume low, moderate, and full-fat emulsions. These results indicate that GL is partially involved in corn oil intake and suggest an interactive effect of oil concentration with homeostatic state.
先前的研究表明，舌咽神经（GL）在膳食脂肪检测中发挥作用。本实验研究了双侧舌咽神经横断术（GLx）对非饥饿、食物剥夺和水剥夺大鼠摄入低（4.8%）、中（16%）和全脂（100%）玉米油的影响。在一个味觉计中，大鼠可以接触到油、0.3M蔗糖和水，该味觉计可测量短暂接触试验期间的舔舐次数和首次舔舐的潜伏期。行为指标分别用作摄入量和摄取动机的指标。在基线摄入量稳定后，大鼠接受GLx或假横断术（假手术），然后重新进行测试。比较手术前后的反应，以确定GLx对摄入量和摄取动机的影响。在非饥饿大鼠中，GLx减少了4.8%和16%油的摄入量，并降低了摄取这些油的动机。在食物剥夺大鼠中，GLx阻止了4.8%和16%油摄入量的增加以及摄取这些油的动机增加。在水剥夺大鼠中，GLx减少了100%油的摄入量，并使摄取低、中、全脂乳液的动机普遍降低。这些结果表明，GL部分参与玉米油的摄入，并提示油浓度与内稳态之间存在交互作用。
