Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Fitoterapia. 2014 Apr;94:114-9. doi: 10.1016/j.fitote.2014.02.002. Epub 2014 Feb 15.
One (formosumone A, 1) new and fifteen (2-16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea ("Kuding Tea") generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibited significant neuroprotective effect against β-amyloid(25-35) (Aβ(25-35))-induced cell viability decrease in SH-SY5Y neuroblastoma cells.
从苦茶替代物（“苦丁茶”），即罗伞属（Cratoxylum formosum ssp. pruniflorum）的叶子中分离得到一种新的（formosumone A，1）和十五种（2-16）已知的酚类化合物。通过广泛的光谱分析和与文献数据的比较确定了它们的结构。化合物 1 具有一个罕见的黄酮与间苯三酚部分偶联的骨架，代表了该骨架首次从铁青树科中分离得到。在所分离的化合物中，发现 toxyloxanthone B（11）和 vismione D（12）通过抑制脂多糖（LPS）刺激的鼠 BV-2 小胶质细胞中一氧化氮（NO）的产生，表现出显著的抗神经炎症作用。此外，toxyloxanthone B（11）在 SH-SY5Y 神经母细胞瘤细胞中对β-淀粉样蛋白（25-35）（Aβ（25-35））诱导的细胞活力下降表现出显著的神经保护作用。
