Eghbal Mohammad Ali, Abdoli Narges, Azarmi Yadollah
Arh Hig Rada Toksikol. 2014 Mar;65(1):101-8. doi: 10.2478/10004-1254-65-2014-2398.
Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 μmol L⁻¹) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive oxygen species formation, lipid peroxidation, mitochondrial membrane potential, and cellular reduced and oxidised glutathione content. Our findings have shown that pretreatment with CoQ10 was effective in reducing the toxic effects of statins in rat hepatocytes. This work demonstrates that the addition of CoQ10 to statin treatment regimens may protect hepatocytes (and also other types of cells) from statin-induced injuries and alleviate their side effects.
他汀类药物是强效降胆固醇药物，可对肌肉和肝脏产生严重不良反应。我们体外研究的目的是通过观察细胞死亡、活性氧形成、脂质过氧化、线粒体膜电位以及细胞内还原型和氧化型谷胱甘肽含量等参数，确定辅酶Q10（CoQ10，最佳剂量为200μmol L⁻¹）对阿托伐他汀、辛伐他汀和洛伐他汀诱导的分离大鼠肝细胞细胞毒性的保护作用。我们的研究结果表明，用CoQ10预处理可有效降低他汀类药物对大鼠肝细胞的毒性作用。这项工作表明，在他汀类药物治疗方案中添加CoQ10可能保护肝细胞（以及其他类型的细胞）免受他汀类药物诱导的损伤并减轻其副作用。
