Jiao Liang, Liu Rui-chang
Department of Anesthesiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Feb 18;46(1):104-6.
To compare the effects between dezocine and flurbiprofen axetil on postoperative sore throat (POST) after maxillofacial procedures.
In the study, 90 adult patients with maxillofacial diseases were divided randomly into control group (group C), flurbiprofen group (group F) and dezocine group (group D). Physiological saline, flurbiprofen axetil (1 mg/kg) and dezocine (0.1 mg/kg) were administered intravenously for each group 30 minutes before the end of the operation. We recorded visual analogue scale (VAS) and Bruggrmann comfort scale (BCS) at the time points of 0.5 h, 1 h, 2 h, and 6 h after extubation.
The incidence of POST in group D decreased significantly (P < 0.05). There was no difference between the incidences of groups F and C. The VAS of group F was lower than that of group C (P < 0.01) just at the time points of 0.5 h and 1 h after extubation, from then on, there was no difference between the 2 groups. The VAS of group D was lower than that of group F, and the BCS was higher than that of group F significantly.
Dezocine has notable analgesia effect for postoperative sore throat, so it is a better choice to carry out postoperative analgesia after maxillofacial procedures.
比较地佐辛与氟比洛芬酯对颌面手术后咽痛（POST）的影响。
本研究将90例成年颌面疾病患者随机分为对照组（C组）、氟比洛芬酯组（F组）和地佐辛组（D组）。每组在手术结束前30分钟静脉注射生理盐水、氟比洛芬酯（1mg/kg）和地佐辛（0.1mg/kg）。记录拔管后0.5小时、1小时、2小时和6小时的视觉模拟评分（VAS）和布罗格曼舒适度评分（BCS）。
D组POST发生率显著降低（P<0.05）。F组和C组发生率无差异。仅在拔管后0.5小时和1小时时，F组的VAS低于C组（P<0.01），此后两组无差异。D组的VAS低于F组，且BCS显著高于F组。
地佐辛对术后咽痛有显著镇痛作用，是颌面手术后进行术后镇痛的较好选择。
