Zheng Mengliang, Guo Yanru, Shan Shiqiang, Yang Sen
Department of Anesthesiology, Cangzhou Central Hospital, Hebei, People's Republic of China.
Patient Prefer Adherence. 2015 Mar 3;9:369-72. doi: 10.2147/PPA.S76507. eCollection 2015.
The purpose of this study was to evaluate the efficacy of dezocine with regard to analgesic and stress reduction outcomes in women undergoing induced abortion.
A total of 126 women in early pregnancy (up to 14 weeks' gestation) who underwent induced abortion at Cangzhou Central Hospital from May 2012 to May 2013 were randomly assigned to a control (propofol) group (n=63) or an intervention (propofol + dezocine) group (n=63). Wake-up time, orientation force recovery time, incidence of adverse reactions, postoperative visual analog scale (VAS) score, analgesic effect, and respiratory and circulatory monitoring before the operation, 5 minutes into the operation, and 5 minutes after the operation were compared between the two groups.
The surgical procedure and anesthesia were performed successfully in all patients. Systolic and diastolic blood pressure and oxyhemoglobin saturation in the intervention group were significantly higher than in the control group; however, heart rate was significantly lower in the intervention group than in the control group 5 minutes into the operation (all P<0.05). There were no statistically significant differences in these parameters before surgery and after recovery. The postoperative VAS score (2.82±0.72), Ramsay score (2.65±0.65), and anesthetic effect in the intervention group were better than in the control group (3.90±0.84 and 2.21±0.49, respectively), and all differences were statistically significant (P<0.05). The wake-up time (3.41±0.79 minutes) and orientation force recovery time (4.28±0.92 minutes) were all significantly shorter (P<0.05) in the intervention group than in the control group, as was the incidence of adverse reactions (7.94% versus 26.98%, respectively).
Adverse reactions of propofol combined with dezocine in painless induced abortion are less while the analgesic effect is better.
本研究旨在评估地佐辛在减轻人工流产女性的疼痛及应激反应方面的疗效。
选取2012年5月至2013年5月在沧州市中心医院接受人工流产的126例早孕（妊娠14周以内）女性，随机分为对照组（丙泊酚组，n = 63）和干预组（丙泊酚 + 地佐辛组，n = 63）。比较两组患者的苏醒时间、定向力恢复时间、不良反应发生率、术后视觉模拟评分（VAS）、镇痛效果以及术前、术中5分钟、术后5分钟的呼吸和循环监测情况。
所有患者手术及麻醉均顺利完成。干预组术中5分钟时收缩压、舒张压及氧合血红蛋白饱和度均显著高于对照组；然而，干预组心率显著低于对照组（均P < 0.05）。术前及恢复后这些参数无统计学差异。干预组术后VAS评分（2.82±0.72）、Ramsay评分（2.65±0.65）及麻醉效果均优于对照组（分别为3.90±0.84和2.21±0.49），且差异均有统计学意义（P < 0.05）。干预组苏醒时间（3.41±0.79分钟）和定向力恢复时间（4.28±0.92分钟）均显著短于对照组（P < 0.05），不良反应发生率也较低（分别为7.94%和26.98%）。
丙泊酚联合地佐辛用于无痛人工流产时不良反应少且镇痛效果好。
