ElMindA Ltd, Haminhara 16 St, Herzliya, Israel, 46586,
J Mol Neurosci. 2014 Sep;54(1):59-70. doi: 10.1007/s12031-014-0250-6. Epub 2014 Feb 18.
The overarching goal of this event-related potential (ERP) study was to examine the effects of scopolamine on the dynamics of brain network activation using a novel ERP network analysis method known as Brain Network Activation (BNA). BNA was used for extracting group-common stimulus-activated network patterns elicited to matching probe stimuli in the context of a delayed matching-to-sample task following placebo and scopolamine treatments administered to healthy participants. The BNA extracted networks revealed the existence of two pathophysiological mechanisms following scopolamine, disconnection, and compensation. Specifically, weaker frontal theta and parietal alpha coupling was accompanied with enhanced fronto-centro-parietal theta activation relative to placebo. In addition, using the characteristic BNA network of each treatment as well as corresponding literature-guided selective subnetworks as combined biomarkers managed to differentiate between individual responses to each of the treatments. Behavioral effects associated with scopolamine included delayed response time and impaired response accuracy. These results indicate that the BNA method is sensitive to the effects of scopolamine on working memory and that it may potentially enable diagnosis and treatment assessment of dysfunctions associated with cholinergic deficiency.
这项事件相关电位 (ERP) 研究的总体目标是使用一种称为脑网络激活 (BNA) 的新型 ERP 网络分析方法，来研究东莨菪碱对大脑网络激活动力学的影响。BNA 用于提取在健康参与者接受安慰剂和东莨菪碱治疗后，在延迟匹配样本任务中，对匹配探测刺激引发的、具有群组共性的刺激激活网络模式。BNA 提取的网络揭示了东莨菪碱作用后存在两种病理生理机制，即断开和补偿。具体来说，与安慰剂相比，较弱的额部 theta 和顶叶 alpha 耦合伴随着额-中-顶叶 theta 激活的增强。此外，使用每种治疗方法的特征性 BNA 网络以及相应的文献指导的选择性子网作为组合生物标志物，成功地区分了对每种治疗方法的个体反应。与东莨菪碱相关的行为效应包括反应时间延迟和反应准确性受损。这些结果表明，BNA 方法对东莨菪碱对工作记忆的影响敏感，并且可能潜在地能够诊断和评估与胆碱能缺乏相关的功能障碍的治疗评估。
