Kiefer Adam W, Barber Foss Kim, Reches Amit, Gadd Brooke, Gordon Michael, Rushford Ken, Laufer Ilan, Weiss Michal, Myer Gregory D
Division of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA ; Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH , USA ; Center for Cognition Action and Perception, Department of Psychology, University of Cincinnati , Cincinnati, OH , USA.
Division of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA.
Front Neurol. 2015 Nov 20;6:243. doi: 10.3389/fneur.2015.00243. eCollection 2015.
Children and adolescent athletes are at a higher risk for concussion than adults, and also experience longer recovery times and increased associated symptoms. It has also recently been demonstrated that multiple, seemingly mild concussions may result in exacerbated and prolonged neurological deficits. Objective assessments and return-to-play criteria are needed to reduce risk and morbidity associated with concussive events in these populations. Recent research has pushed to study the use of electroencephalography as an objective measure of brain injury. In the present case study, we present a novel approach that examines event-related potentials via a brain network activation (BNA) analysis as a biomarker of concussion and recovery. Specifically, changes in BNA scores, as indexed through this approach, offer a potential indicator of neurological health as the BNA assessment qualitatively and quantitatively indexes the network dynamics associated with brain injury. Objective tools, such as these support accurate and efficient assessment of brain injury and may offer a useful step in categorizing the temporal and spatial changes in brain activity following concussive blows, as well as the functional connectivity of brain networks, associated with concussion.
儿童和青少年运动员比成年人更容易发生脑震荡，并且恢复时间更长，相关症状也会增加。最近还证明，多次看似轻微的脑震荡可能会导致神经功能缺损加剧和持续时间延长。需要进行客观评估和制定重返比赛标准，以降低这些人群中与脑震荡事件相关的风险和发病率。最近的研究推动了对使用脑电图作为脑损伤客观测量方法的研究。在本案例研究中，我们提出了一种新方法，通过脑网络激活（BNA）分析来检查事件相关电位，作为脑震荡和恢复的生物标志物。具体而言，通过这种方法得出的BNA分数变化，可作为神经健康的潜在指标，因为BNA评估从定性和定量两方面对与脑损伤相关的网络动态进行了索引。诸如此类的客观工具有助于准确、高效地评估脑损伤，并可能为对脑震荡打击后大脑活动的时空变化以及与脑震荡相关的脑网络功能连接进行分类提供有益的帮助。
