Department of Biomedical Science, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
Phytother Res. 2014 Aug;28(8):1246-51. doi: 10.1002/ptr.5126. Epub 2014 Feb 17.
Salicin has been studied as a potent antiinflammatory agent. Angiogenesis is an essential process for tumor progression, and negative regulation of angiogenesis provides a good strategy for antitumor therapy. However, the potential medicinal value of salicin on antitumorigenic and antiangiogenic effects remain unexplored. In this study, we examined the antitumorigenic and antiangiogenic activity of salicin and its underlying mechanism of action. Salicin suppressed the angiogenic activity of endothelial cells, such as migration, tube formation, and sprouting from an aorta. Moreover, salicin reduced reactive oxygen species production and activation of the extracellular signal-regulated kinase pathway. The expression of vascular endothelial growth factor was also decreased by salicin in endothelial cells. When the salicin was administered to mice, salicin inhibited tumor growth and angiogenesis in a mouse tumor model. Taken together, salicin targets the signaling pathways mediated by reactive oxygen species and extracellular signal-regulated kinase, providing new perspectives into a potent therapeutic agent for hypervascularized tumors.
柳醇已被研究作为一种有效的抗炎剂。血管生成是肿瘤进展的一个必要过程，而对血管生成的负向调节为抗肿瘤治疗提供了一个很好的策略。然而，柳醇在抗肿瘤和抗血管生成作用方面的潜在药用价值仍未得到探索。在这项研究中，我们研究了柳醇的抗肿瘤和抗血管生成活性及其作用机制。柳醇抑制了内皮细胞的血管生成活性，如迁移、管形成和从主动脉的出芽。此外，柳醇还减少了活性氧的产生和细胞外信号调节激酶途径的激活。柳醇还能降低内皮细胞中血管内皮生长因子的表达。当柳醇被给予小鼠时，柳醇抑制了小鼠肿瘤模型中的肿瘤生长和血管生成。综上所述，柳醇靶向由活性氧和细胞外信号调节激酶介导的信号通路，为富血管化肿瘤提供了一种有效的治疗药物。
