Department of Biomedical Science, Kyung Hee University, Seoul, Korea.
Phytother Res. 2013 Jun;27(6):841-6. doi: 10.1002/ptr.4800. Epub 2012 Aug 16.
Glycyrrhizic acid (GA) is the bioactive compound of licorice and has been used as a herbal medicine because of its anti-viral, anti-cancer, and anti-inflammatory properties. This study was designed to investigate the effects of GA on tumor growth, angiogenesis, and the mechanisms underlying the anti-angiogenic activities of GA. We observed that GA inhibited tumor growth and angiogenesis in mice. GA decreased angiogenic activities, such as the migration, invasion, and tube formation of endothelial cells. We also demonstrated that GA reduced the production of reactive oxygen species and activation of ERK in endothelial cells. Our findings suggest that GA is a promising anti-angiogenic therapeutic agent that targets the ERK pathway. Considering that angiogenesis is highly stimulated in the majority of cancers, GA could offer a potent therapeutic agent for cancer.
甘草酸（GA）是甘草的生物活性化合物，由于其抗病毒、抗癌和抗炎特性，已被用作草药。本研究旨在探讨 GA 对肿瘤生长、血管生成以及 GA 抗血管生成作用机制的影响。我们观察到 GA 抑制了小鼠的肿瘤生长和血管生成。GA 降低了血管生成活性，如内皮细胞的迁移、侵袭和管形成。我们还表明，GA 减少了内皮细胞中活性氧的产生和 ERK 的激活。我们的研究结果表明，GA 是一种有前途的靶向 ERK 通路的抗血管生成治疗剂。考虑到血管生成在大多数癌症中受到高度刺激，GA 可能为癌症提供一种有效的治疗剂。
