Sauk J J, Norris K
Department of Oral Pathology, University of Maryland at Baltimore 21201.
J Oral Pathol. 1988 Jan;17(1):30-3. doi: 10.1111/j.1600-0714.1988.tb01501.x.
Guinea pig epidermal keratinocytes were harvested and grown in vitro (20). The cells were treated with polyphenolic compounds, acetate/shikimate aromatics, that are ubiquitous in plants. In addition, the cells were exposed to tobacco glycoprotein (TGP), a plant-derived substance prepared from cured tobacco (19). All of the polyphenolic compounds enhanced the attachment of cells to a defined substratum and inhibited cell proliferation. Tobacco glycoprotein (TGP), rutin conjugates and ellagic acid inhibited cell spreading and enhanced the apparent microviscosity of keratinocyte membrane lipids. These data suggest that the use of these compounds may be associated with alterations in cytoskeletal architecture and membrane fluid dynamics that might result in clinical alterations characterized by whitening of mucosae.
豚鼠表皮角质形成细胞被收获并在体外培养（20）。这些细胞用植物中普遍存在的多酚类化合物、乙酸盐/莽草酸芳香族化合物处理。此外，细胞暴露于烟草糖蛋白（TGP），一种从烤烟制备的植物源物质（19）。所有的多酚类化合物都增强了细胞与特定基质的附着，并抑制细胞增殖。烟草糖蛋白（TGP）、芦丁缀合物和鞣花酸抑制细胞铺展并增强角质形成细胞膜脂质的表观微粘度。这些数据表明，使用这些化合物可能与细胞骨架结构和膜流体动力学的改变有关，这可能导致以粘膜变白为特征的临床改变。
