烟草成分对动脉平滑肌细胞有促有丝分裂作用。
Tobacco constituents are mitogenic for arterial smooth-muscle cells.
作者信息
Becker C G, Hajjar D P, Hefton J M
出版信息
Am J Pathol. 1985 Jul;120(1):1-5.
Abstract
Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
摘要
从烤烟叶片中纯化得到的烟草糖蛋白（TGP）、焦油衍生物质（TAR）、香烟烟雾冷凝物的水溶性、不可透析、脱脂提取物、芦丁 - 牛血清白蛋白缀合物、槲皮素和绿原酸对牛主动脉平滑肌细胞具有促有丝分裂作用，但对血管外膜成纤维细胞没有作用。这种促有丝分裂作用似乎取决于载体分子上的多酚表位。另一种植物多酚鞣花酸可抑制动脉平滑肌增殖。这些结果表明，许多普遍存在的植物衍生物质可能会影响动脉壁平滑肌细胞的增殖。
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本文引用的文献
1
ACTIVATION OF HAGEMAN FACTOR BY SOLUTIONS OF ELLAGIC ACID.
J Lab Clin Med. 1964 Mar;63:359-77.
2
The role of smooth muscle cells in the fibrogenesis of arteriosclerosis.
Am J Pathol. 1960 Oct;37(4):377-89.
3
The mass uptake of cholesterol ester from low density lipoproteins by cultured smooth muscle and adventitial cells of human aortas.
Circ Res. 1980 Sep;47(3):374-83. doi: 10.1161/01.res.47.3.374.
4
Tobacco, cocoa, coffee, and ragweed: cross-reacting allergens that activate factor-XII-dependent pathways.
Blood. 1981 Nov;58(5):861-7.
5
Induction of acalculous cholecystitis and pneumonitis in dogs following inhalation of constituents of cigarette smoke condensate.
Am J Pathol. 1982 Dec;109(3):253-8.
6
A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds.
Mutat Res. 1980 May;75(3):243-77. doi: 10.1016/0165-1110(80)90029-9.
7
Role of antigen structure in the regulation of IgE isotype expression.
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3430-4. doi: 10.1073/pnas.80.11.3430.
8
9
Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells.
J Clin Invest. 1982 Sep;70(3):479-88. doi: 10.1172/jci110639.
10
A radial immune-gel filtration method for characterization and quantitation of macromolecules.
Int Arch Allergy Appl Immunol. 1971;40(6):806-19. doi: 10.1159/000230464.
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