Becker C G, Hajjar D P, Hefton J M
Am J Pathol. 1985 Jul;120(1):1-5.
Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
从烤烟叶片中纯化得到的烟草糖蛋白（TGP）、焦油衍生物质（TAR）、香烟烟雾冷凝物的水溶性、不可透析、脱脂提取物、芦丁 - 牛血清白蛋白缀合物、槲皮素和绿原酸对牛主动脉平滑肌细胞具有促有丝分裂作用，但对血管外膜成纤维细胞没有作用。这种促有丝分裂作用似乎取决于载体分子上的多酚表位。另一种植物多酚鞣花酸可抑制动脉平滑肌增殖。这些结果表明，许多普遍存在的植物衍生物质可能会影响动脉壁平滑肌细胞的增殖。
