Nicklas W, Giese M, Zawatzky R, Kirchner H, Eaton P
Central Animal Laboratories, German Cancer Research Centre, Heidelberg, FRG.
Lab Anim Sci. 1988 Apr;38(2):152-4.
Interferon induction occurred unexpectedly during an in vivo study using a mouse monoclonal antibody. The interferon was typed alpha/beta and the titer reached a maximum at 24 hours in contrast with other inducers. Similar results were obtained with a virus pool derived from the antibody and with a LDV reference strain. MAP-testing of the monoclonal antibody revealed contamination with lactate dehydrogenase virus (LDV). The production of IFN seems to be controlled genetically. This experimental error demonstrates the importance of an appropriate quality control of biological materials.
在一项使用小鼠单克隆抗体的体内研究中意外发生了干扰素诱导现象。所诱导的干扰素类型为α/β，与其他诱导剂相比，其效价在24小时时达到最高。使用源自该抗体的病毒库和乳酸脱氢酶病毒（LDV）参考毒株也获得了类似结果。对该单克隆抗体进行的MAP检测显示其被乳酸脱氢酶病毒（LDV）污染。干扰素的产生似乎受基因控制。这一实验误差证明了对生物材料进行适当质量控制的重要性。
