Panerai A E, Sacerdote P, Brini A, Bianchi M, Mantegazza P
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Peptides. 1988 Mar-Apr;9(2):319-24. doi: 10.1016/0196-9781(88)90267-7.
Beta-endorphin, Met-enkephalin, substance P, somatostatin and dynorphin concentrations were evaluated in right and left brain areas, and in cervical, thoracic, and lumbosacral spinal cord of rats that underwent section of either the right, the left, both sciatic nerves, the right brachial plexus, the saphenous, or the sural nerve. With all the surgeries, beta-endorphin concentrations decreased significantly in all brain areas with the exception of the striatum where they did not change. By contrast Met-enkephalin increased in all brain areas and in the spinal cord tracts interested by the lesions. The other peptides were always unaffected. The changes in the concentrations of the neuropeptides were observed starting twenty-four hours after surgery and lasted for at least four months. We did not find a lateralization in the brain peptide concentrations of either sham operated or unilaterally deafferentated rats. Moreover, the treatment with serotoninergic agents normalized the concentrations of beta-endorphin, suggesting a role of the serotoninergic system in the decrease of the peptide that follows the lesion of peripheral nerves.
在接受右侧、左侧、双侧坐骨神经、右侧臂丛神经、隐神经或腓肠神经切断术的大鼠的左右脑区以及颈、胸和腰骶脊髓中，评估了β-内啡肽、甲硫氨酸脑啡肽、P物质、生长抑素和强啡肽的浓度。在所有手术中，除纹状体中β-内啡肽浓度未改变外，所有脑区的β-内啡肽浓度均显著降低。相比之下，甲硫氨酸脑啡肽在所有脑区以及受损伤影响的脊髓束中均增加。其他肽类则始终未受影响。神经肽浓度的变化在术后24小时开始出现，并持续至少四个月。我们在假手术或单侧去传入神经的大鼠的脑肽浓度中未发现偏侧化现象。此外，血清素能药物治疗使β-内啡肽浓度恢复正常，这表明血清素能系统在周围神经损伤后肽类减少中发挥作用。
