Sacerdote P, Carrabba M, Galante A, Pisati R, Manfredi B, Panerai A E
Department of Pharmacology, University of Milan, Italy.
Inflamm Res. 1995 Nov;44(11):486-90. doi: 10.1007/BF01837915.
We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients. All patients had high synovial fluid cytokine and substance P levels, and high plasma cytokine levels at the beginning of the study. The treatment with the non steroidal anti inflammatory drugs significantly decreased both plasma and synovial fluid IL-6 and synovial fluid substance P in comparison to placebo, but did not affect IL-1 beta concentrations. This effect can participate in the therapeutic effect of non steroidal anti inflammatory drugs in rheumatoid arthritis.
我们进行了一项开放性、患者间、安慰剂对照研究，以评估非甾体抗炎药吲哚美辛、双氯芬酸和萘普生对24例类风湿性关节炎患者血浆和滑液中细胞因子IL-1β和IL-6以及神经肽P物质浓度的影响。在研究开始时，所有患者的滑液细胞因子和P物质水平以及血浆细胞因子水平均较高。与安慰剂相比，非甾体抗炎药治疗显著降低了血浆和滑液中的IL-6以及滑液中的P物质，但未影响IL-1β浓度。这种作用可能参与了非甾体抗炎药对类风湿性关节炎的治疗效果。
