猪淋巴细胞抗原定义的小型猪中的干扰素诱导
Interferon induction in swine lymphocyte antigen-defined miniature pigs.
作者信息
Jordan L T, Derbyshire J B, Mallard B A
机构信息
Department of Veterinary Microbiology and Immunology, University of Guelph, Canada.
出版信息
Res Vet Sci. 1995 May;58(3):282-3. doi: 10.1016/0034-5288(95)90118-3.
Interferon was induced in two groups of swine lymphocyte antigen (SLA)-defined miniature pigs with polyinosinic: polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. The group 1 pigs were low antibody-response phenotypes (SLAa/a, SLAa/c, SLAc/c), and the group 2 pigs were high antibody-response phenotypes (SLAd/d, SLAd/g, SLAg/g). Six hours after induction the antiviral tires were not influenced by the SLA group, but higher titres were observed in females. Higher antiviral titres were found in group 2 pigs before treatment and 24 hours after treatment, and higher titres were found in female pigs. The antiviral titres before and after treatment were also influenced by the sire. Group 2 pigs had a lower total leucocyte counts before treatment, and there was a significant reduction in leucocyte numbers in both groups six hours after induction, due mainly to a large reduction in lymphocyte counts.
用与聚-L-赖氨酸和羧甲基纤维素复合的聚肌苷酸:聚胞苷酸诱导两组猪淋巴细胞抗原(SLA)定义的小型猪产生干扰素。第1组猪是低抗体反应表型(SLAa/a、SLAa/c、SLAc/c)，第2组猪是高抗体反应表型(SLAd/d、SLAd/g、SLAg/g)。诱导后6小时，抗病毒滴度不受SLA组影响，但在雌性猪中观察到更高的滴度。在治疗前和治疗后24小时，第2组猪的抗病毒滴度更高，雌性猪的滴度也更高。治疗前后的抗病毒滴度也受父系影响。第2组猪在治疗前的白细胞总数较低，诱导后6小时两组的白细胞数量均显著减少，主要是由于淋巴细胞数量大幅减少。
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