Domagala W, Halczy-Kowalik L, Weber K, Osborn M
Department of Tumor Pathology, Medical Academy, Szczecin, Poland.
Acta Cytol. 1988 May-Jun;32(3):403-8.
Positive staining for glial fibrillary acidic protein (GFAP) of tumor cells in fine needle aspirates of 11 of 12 pleomorphic adenomas of the parotid gland is reported. Tumor cells in these neoplasms also coexpressed keratin and vimentin to varying extents. Coexpression of GFAP, keratin and vimentin in tumor cells in aspirates is an unusual feature, so far demonstrated only in pleomorphic adenomas. Thus, intermediate filament typing may help to distinguish: (1) pleomorphic adenomas of the salivary glands from head and neck tumors of nonsalivary gland origin; (2) intracranial metastases of malignant mixed tumors of the salivary gland from gliomas; and (3) pleomorphic adenomas from extracranial gliomas.
据报道，在12例腮腺多形性腺瘤中，有11例的细针穿刺抽吸物中的肿瘤细胞胶质纤维酸性蛋白（GFAP）呈阳性染色。这些肿瘤中的肿瘤细胞还不同程度地共表达角蛋白和波形蛋白。抽吸物中肿瘤细胞GFAP、角蛋白和波形蛋白的共表达是一个不寻常的特征，迄今为止仅在多形性腺瘤中得到证实。因此，中间丝分型可能有助于区分：（1）涎腺多形性腺瘤与非涎腺来源的头颈部肿瘤；（2）涎腺恶性混合瘤的颅内转移瘤与神经胶质瘤；（3）多形性腺瘤与颅外神经胶质瘤。
