Gupta R K, Naran S, Dowle C, Simpson J S
Department of Cytology, Wellington Hospital and School of Medicine, New Zealand.
Cytopathology. 1992;3(5):303-9. doi: 10.1111/j.1365-2303.1992.tb00052.x.
An unusual coexpression of glial fibrillary acid protein (GFAP), keratin and vimentin occurs in pleomorphic adenoma of salivary gland. We designed this study to see if coexpression of the markers was also present in monomorphic adenoma of the salivary gland and whether monomorphic adenoma could be distinguished from other salivary gland tumours by marker studies. Immunocytochemical markers were used on fine needle aspiration samples from four cases of monomorphic adenoma, two cases of oncocytic adenoma, three cases of adenoid cystic carcinoma and four cases of pleomorphic adenoma. While positivity for cytokeratin, vimentin and S-100 was consistently found in all cases of monomorphic adenoma, only cytokeratin was expressed in adenoid cystic carcinoma. In pleomorphic adenoma, GFAP, cytokeratin and vimentin were coexpressed while in cases of oncocytic adenoma none of the markers was localized. Thus, it appears that by using a combination of GFAP, cytokeratin, vimentin and S-100 a distinction between these neoplasms may be possible. However, a larger study is needed to establish the usefulness of this approach.
胶质纤维酸性蛋白（GFAP）、角蛋白和波形蛋白在涎腺多形性腺瘤中存在异常共表达。我们开展本研究旨在观察这些标志物的共表达是否也存在于涎腺单形性腺瘤中，以及单形性腺瘤能否通过标志物研究与其他涎腺肿瘤相鉴别。对4例单形性腺瘤、2例嗜酸细胞腺瘤、3例腺样囊性癌和4例多形性腺瘤的细针穿刺样本进行免疫细胞化学标志物检测。所有单形性腺瘤病例均始终检测到细胞角蛋白、波形蛋白和S-100呈阳性，而腺样囊性癌仅表达细胞角蛋白。在多形性腺瘤中，GFAP、细胞角蛋白和波形蛋白共表达，而在嗜酸细胞腺瘤病例中未检测到任何标志物定位。因此，似乎通过联合使用GFAP、细胞角蛋白、波形蛋白和S-100，有可能区分这些肿瘤。然而，需要更大规模的研究来证实这种方法的有效性。
