Ostrzega N, Cheng L, Layfield L
Department of Pathology, UCLA School of Medicine 90024.
Diagn Cytopathol. 1989;5(2):145-9. doi: 10.1002/dc.2840050207.
The value of immunocytochemical staining for glial fibrillary acid protein (GFAP) in salivary gland lesions was investigated in 33 fine-needle aspiration smears. The study utilized cytologic material from ten pleomorphic adenomas, six normal salivary glands, three cases of chronic sialadenitis, three Warthin's tumors, two adenoid cystic carcinomas, three adenocarcinomas, two malignant mixed tumors, one acinic cell carcinoma, and three mucoepidermoid carcinomas. All tested pleomorphic adenomas stained positively. The adenoid cystic carcinomas and the cases of chronic sialadenitis, along with the low-grade mucoepidermoid carcinoma, were negative for GFAP immunoreactivity. These results indicate that immunostaining for GFAP may be a valuable aid in the diagnosis of pleomorphic adenoma; GFAP may be especially helpful in distinguishing those cases for which the differential diagnosis includes the aforementioned salivary gland neoplasms.
在33份细针穿刺涂片标本中，对唾液腺病变进行了胶质纤维酸性蛋白（GFAP）免疫细胞化学染色价值的研究。该研究使用了来自10例多形性腺瘤、6例正常唾液腺、3例慢性涎腺炎、3例沃辛瘤、2例腺样囊性癌、3例腺癌、2例恶性混合瘤、1例腺泡细胞癌和3例黏液表皮样癌的细胞学材料。所有检测的多形性腺瘤均呈阳性染色。腺样囊性癌、慢性涎腺炎病例以及低级别黏液表皮样癌的GFAP免疫反应呈阴性。这些结果表明，GFAP免疫染色可能有助于多形性腺瘤的诊断；GFAP在鉴别诊断包括上述唾液腺肿瘤的病例中可能特别有用。
