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足底角质层中桥粒的蛋白水解降解导致体外细胞解离。

Proteolytic degradation of desmosomes in plantar stratum corneum leads to cell dissociation in vitro.

作者信息

Egelrud T, Hofer P A, Lundström A

机构信息

Department of Dermatology, University Hospital, Umeå, Sweden.

出版信息

Acta Derm Venereol. 1988;68(2):93-7.

PMID:2454007
Abstract

Pieces of plantar stratum corneum were incubated with trypsin. This resulted in cell dissociation. The only observable ultrastructural change caused by trypsin was a degradation of desmosomal plates between dissociating cells. This suggests that desmosomes are of primary importance in plantar stratum corneum cell adhesion.

摘要

将足底角质层碎片用胰蛋白酶进行孵育。这导致了细胞解离。胰蛋白酶引起的唯一可观察到的超微结构变化是解离细胞间桥粒板的降解。这表明桥粒在足底角质层细胞黏附中至关重要。

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Proteolytic degradation of desmosomes in plantar stratum corneum leads to cell dissociation in vitro.足底角质层中桥粒的蛋白水解降解导致体外细胞解离。
Acta Derm Venereol. 1988;68(2):93-7.
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Intercellular lamellar lipids in plantar stratum corneum.足底角质层中的细胞间层状脂质
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Action of trypsin on human plantar stratum corneum. An ultrastructural study.胰蛋白酶对人足底角质层的作用。一项超微结构研究。
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Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation.角质溶解素是一种在角质形成过程中可能用于修饰桥粒的蛋白质，它在角质层细胞黏附和脱屑中发挥作用的证据。
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Electron microscopy of normal human plantar epidermis. 1. Strata lucidum and corneum.
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Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation.在表皮脱屑过程中，组织蛋白酶D而非组织蛋白酶E可降解桥粒。
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Some ultrastructural observations on the dermo-epidermal junction. Effect of electron stains (phosphotungstic acid, lanthanum) and in vitro trypsin digestion.关于真皮-表皮连接处的一些超微结构观察。电子染色剂（磷钨酸、镧）的作用及体外胰蛋白酶消化的影响。
Acta Derm Venereol Suppl (Stockh). 1973;73:111-9.

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Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade.
激肽释放酶相关肽酶-8（KLK8）是人类表皮和汗液中一种具有活性的丝氨酸蛋白酶，参与皮肤屏障蛋白水解级联反应。
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