Ichimura K, Mineda H, Seki A
Department of Otolaryngology, Tokyo Metropolitan Fuchu Hospital, Japan.
Ann Otol Rhinol Laryngol. 1988 May-Jun;97(3 Pt 1):289-93. doi: 10.1177/000348948809700316.
We used dog nasal blood vessels and an in vitro muscle tension-detecting technique to examine the vascular effects of several neuropeptides: vasoactive intestinal polypeptide, substance P, neurotensin, somatostatin, and neuropeptide Y (NPY). Electrically induced vasoconstriction was inhibited by every peptide except neurotensin, which enhanced this response. Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction. Only NPY caused a tissue contraction. Preparations precontracted by methoxamine were relaxed by every peptide. These results indicate that all peptides examined have marked but varied vasoactivities.
我们使用犬鼻血管和体外肌肉张力检测技术，研究了几种神经肽的血管效应：血管活性肠肽、P物质、神经降压素、生长抑素和神经肽Y（NPY）。除神经降压素增强电诱导的血管收缩反应外，其他每种肽均抑制该反应。用生长抑素处理的每种制剂以及用NPY处理的一个组织，去甲肾上腺素诱导的收缩均增强。只有NPY引起组织收缩。用甲氧明预收缩的制剂，每种肽均可使其舒张。这些结果表明，所检测的所有肽均具有显著但不同的血管活性。
