Hauser-Kronberger C E, Hacker G W, Sundler F, Thurner J, Albegger K
Institute of Zoology, University of Salzburg, Austria.
Eur Arch Otorhinolaryngol. 1992;249(4):201-5. doi: 10.1007/BF00178469.
Regulatory peptide immunoreactivities reported in the upper respiratory system of man include vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), which are co-localized in a network of fine varicose nerve fibers. The present study was undertaken to examine the possible occurrence and distribution of the recently described VIP-like peptide helospectin. Double immunofluorescence labelling showed that helospectin is co-localized with VIP and PHM. In addition to nerve fibers containing all three peptides, scattered nerve fibers were detected that were only immunoreactive to helospectin but not to VIP and/or PHM. The distribution of helospectin/VIP/PHM immunoreactive nerve fibers around blood vessels and in close relationship to seromucous glands indicates their possible involvement in the regulation of blood flow and secretion.
在人类上呼吸道中发现的调节肽免疫反应包括血管活性肠肽（VIP）和肽组氨酸甲硫氨酸（PHM），它们共定位于细的曲张神经纤维网络中。本研究旨在检测最近描述的类VIP肽helospectin的可能存在情况及其分布。双重免疫荧光标记显示，helospectin与VIP和PHM共定位。除了含有所有三种肽的神经纤维外，还检测到一些散在的神经纤维，它们仅对helospectin有免疫反应，而对VIP和/或PHM无免疫反应。helospectin/VIP/PHM免疫反应性神经纤维在血管周围以及与浆液性腺密切相关的分布表明，它们可能参与了血流和分泌的调节。
