色甘酸钠对肥大细胞作用之谜。
Enigma of disodium cromoglycate action on mast cells.
作者信息
Krüger P G, Bloom G D
出版信息
Int Arch Allergy Appl Immunol. 1979;60(1):110-4. doi: 10.1159/000232330.
PMID:88418
Abstract
In rat peritoneal mast cells, disodium cromoglycate showed no inhibitory effect on histamine release values if the cells were preincubated with the drug for 40 min prior to stimulation with antigen, compound 48/80 or ATP. If the drug was added simultaneously with antigen or a low dose of compound 48/80, a repression of histamine release occurred. No such effect was noted if ATP was employed as histamine liberator.
摘要
在大鼠腹膜肥大细胞中，如果在抗原、化合物48/80或ATP刺激前，将细胞与色甘酸二钠预孵育40分钟，色甘酸二钠对组胺释放值没有抑制作用。如果该药物与抗原或低剂量的化合物48/80同时添加，则会抑制组胺释放。如果使用ATP作为组胺释放剂，则未观察到这种效应。
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