• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse.

作者信息

Fujita N, Sato S, Kurihara T, Inuzuka T, Takahashi Y, Miyatake T

机构信息

Department of Neurology, Niigata University, Japan.

出版信息

FEBS Lett. 1988 May 23;232(2):323-7. doi: 10.1016/0014-5793(88)80762-2.

DOI:10.1016/0014-5793(88)80762-2
PMID:2454205
Abstract

Evidence is presented that expression of the two myelin-associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse.

摘要

相似文献

1
Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse.
FEBS Lett. 1988 May 23;232(2):323-7. doi: 10.1016/0014-5793(88)80762-2.
2
cDNA cloning of mouse myelin-associated glycoprotein: a novel alternative splicing pattern.
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1162-9. doi: 10.1016/0006-291x(89)92724-1.
3
The large isoform of myelin-associated glycoprotein is scarcely expressed in the quaking mouse brain.髓鞘相关糖蛋白的大型异构体在震颤小鼠大脑中几乎不表达。
J Neurochem. 1990 Sep;55(3):1056-9. doi: 10.1111/j.1471-4159.1990.tb04596.x.
4
Differential splicing of MAG transcripts during CNS and PNS development.在中枢神经系统和外周神经系统发育过程中MAG转录本的差异剪接。
Brain Res. 1988 Sep;464(2):143-55. doi: 10.1016/0169-328x(88)90006-x.
5
cDNA cloning and amino acid sequence for human myelin-associated glycoprotein.
Biochem Biophys Res Commun. 1989 Sep 29;163(3):1473-80. doi: 10.1016/0006-291x(89)91145-5.
6
The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice.
Gene. 1987;55(2-3):333-7. doi: 10.1016/0378-1119(87)90293-9.
7
Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice.正常和脱髓鞘突变小鼠中髓鞘蛋白脂蛋白和碱性蛋白mRNA的发育表达。
J Neurochem. 1987 Oct;49(4):1146-54. doi: 10.1111/j.1471-4159.1987.tb10005.x.
8
Function of quaking in myelination: regulation of alternative splicing.震颤蛋白在髓鞘形成中的作用：可变剪接的调控
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4233-8. doi: 10.1073/pnas.072090399. Epub 2002 Mar 26.
9
Expression of myelin protein genes in quaking mouse brain.
J Neurosci Res. 1988 May;20(1):19-22. doi: 10.1002/jnr.490200104.
10
DM20 mRNA splice product of the myelin proteolipid protein gene is expressed in the murine heart.
J Neurosci Res. 1992 Sep;33(1):148-55. doi: 10.1002/jnr.490330119.

引用本文的文献

1
Circular RNAs as Therapeutic Agents and Targets.环状RNA作为治疗剂和靶点
Front Physiol. 2018 Oct 9;9:1262. doi: 10.3389/fphys.2018.01262. eCollection 2018.
2
Molecular functions and specific roles of circRNAs in the cardiovascular system.环状RNA在心血管系统中的分子功能及特定作用
Noncoding RNA Res. 2018 May 14;3(2):75-98. doi: 10.1016/j.ncrna.2018.05.002. eCollection 2018 Jun.
3
RNA-binding Protein Quaking Stabilizes mRNA during Oligodendroglial Differentiation.RNA结合蛋白Quaking在少突胶质细胞分化过程中稳定mRNA
J Biol Chem. 2017 Mar 31;292(13):5166-5182. doi: 10.1074/jbc.M117.775544. Epub 2017 Feb 10.
4
Inferring transcript phylogenies.推断转录系统发生。
BMC Bioinformatics. 2012 Jun 11;13 Suppl 9(Suppl 9):S1. doi: 10.1186/1471-2105-13-s9-s1.
5
Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.摇蚊 I 控制着一种独特的细胞质途径，该途径调节髓鞘相关糖蛋白的可变剪接。
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19061-6. doi: 10.1073/pnas.1007487107. Epub 2010 Oct 18.
6
Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development.选择性RNA结合蛋白QKI在中枢神经系统髓鞘发育中的基本功能、复杂调控及病理影响
Future Neurol. 2008 Nov;3(6):655-668. doi: 10.2217/14796708.3.6.655.
7
The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination.大的髓鞘相关糖蛋白异构体的胞质结构域是中枢神经系统正常髓鞘形成所必需的，但不是周围神经系统髓鞘形成所必需的。
J Neurosci. 1998 Mar 15;18(6):1970-8. doi: 10.1523/JNEUROSCI.18-06-01970.1998.
8
The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos.由震颤蛋白编码的KH结构域蛋白以二聚体形式发挥作用，对非洲爪蟾胚胎的脊索发育至关重要。
Genes Dev. 1997 Sep 1;11(17):2176-90. doi: 10.1101/gad.11.17.2176.
9
Endocytic depletion of L-MAG from CNS myelin in quaking mice.震颤小鼠中枢神经系统髓鞘中L-MAG的内吞性耗竭。
J Cell Biol. 1995 Dec;131(6 Pt 2):1811-20. doi: 10.1083/jcb.131.6.1811.
10
A sequence compilation and comparison of exons that are alternatively spliced in neurons.在神经元中可变剪接的外显子的序列汇编与比较。
Nucleic Acids Res. 1994 May 11;22(9):1515-26. doi: 10.1093/nar/22.9.1515.