Fujita N, Sato S, Kurihara T, Kuwano R, Sakimura K, Inuzuka T, Takahashi Y, Miyatake T
Department of Neurology, Niigata University, Japan.
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1162-9. doi: 10.1016/0006-291x(89)92724-1.
The structures of three forms of mouse myelin-associated glycoprotein mRNAs were determined from full-length cDNA clones. Two forms of mRNAs have been reported to be different by alternate inclusion of exon 2 and 12 in rat brain. One of the three forms of clones obtained here appeared to be a novel mRNA which lacked both the exon 2 and 12 portions, although others were identical splicing patterns to those of rat. Northern blot analysis using specific probes to mRNAs with or without the exon 2 portion in normal and quaking mouse confirmed that the splicing of exon 2 and 12 occurred independently.
