TNO (a Dutch acronym for Netherlands Organisation of Applied Scientific Research), Zeist, the Netherlands.
Diabetol Metab Syndr. 2014 Feb 18;6(1):24. doi: 10.1186/1758-5996-6-24.
Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin-A.
We analyzed data of three separate open-label, randomized, crossover trials: 1) 36 postmenopausal women consuming 250 ml white wine (25 g alcohol) or white grape juice daily for 6 weeks, 2) 24 premenopausal women consuming 660 ml beer (26 g alcohol) or alcohol-free beer daily for 3 weeks, and 3) 24 young men consuming 100 ml vodka (30 g alcohol) orange juice or only orange juice daily for 4 weeks. After each treatment period fasting blood samples were collected.
Circulating fetuin-A concentrations decreased in men after vodka consumption (Mean ± SEM: 441 ± 11 to 426 ± 11 μg/ml, p = 0.02), but not in women after wine (448 ± 17 to 437 ± 17 μg/ml, p = 0.16) or beer consumption (498 ± 15 to 492 ± 15 μg/ml, p = 0.48) compared to levels after each corresponding alcohol-free treatment. Post-hoc power analyses indicated that the statistical power to detect a similar effect as observed in men was 30% among the postmenopausal women and 31% among the premenopausal women.
In these randomized crossover trials, moderate alcohol consumption decreased fetuin-A in men but not in women. This sex-specific effect may be explained by the relatively short intervention periods or the low statistical power in the trials among women.
ClinicalTrials.gov ID no's: NCT00285909, NCT00524550, NCT00918918.
胎球蛋白 A 是一种肝脏来源的糖蛋白，可损害胰岛素信号，已成为糖尿病风险的生物标志物。尽管中等量饮酒与胎球蛋白 A 呈负相关，但临床试验的数据却缺乏。因此，我们评估了中等量饮酒是否会降低循环胎球蛋白 A 水平。
我们分析了三项单独的开放性、随机、交叉试验的数据：1）36 名绝经后妇女每天饮用 250ml 白葡萄酒（25g 酒精）或白葡萄汁，持续 6 周；2）24 名绝经前妇女每天饮用 660ml 啤酒（26g 酒精）或无酒精啤酒，持续 3 周；3）24 名年轻男性每天饮用 100ml 伏特加（30g 酒精）橙汁或仅橙汁，持续 4 周。在每个治疗期结束后采集空腹血样。
男性在饮用伏特加后循环胎球蛋白 A 浓度下降（平均值±SEM：441±11 至 426±11μg/ml，p=0.02），但女性在饮用白葡萄酒（448±17 至 437±17μg/ml，p=0.16）或啤酒（498±15 至 492±15μg/ml，p=0.48）后，与各自相应的无酒精处理后相比，浓度并无差异。事后检验的功效分析表明，在绝经后妇女中，检测到与男性相似效果的统计功效为 30%，在绝经前妇女中为 31%。
在这些随机交叉试验中，中等量饮酒可降低男性而非女性的胎球蛋白 A。这种性别特异性效应可能是由于干预期相对较短，或女性试验中的统计功效较低所致。
ClinicalTrials.gov ID 号：NCT00285909、NCT00524550、NCT00918918。
