Rodríguez-Nunez Iván, Wcisel Dustin J, Litman Gary W, Yoder Jeffrey A
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA.
Department of Pediatrics, University of South Florida College of Medicine, USF/ACH Children's Research Institute, 140 7th Avenue South, St. Petersburg, FL 33701, USA; Department of Molecular Genetics, All Children's Hospital, 501 6th Avenue South, St. Petersburg, FL 33701, USA; H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Dev Comp Immunol. 2014 Sep;46(1):24-34. doi: 10.1016/j.dci.2014.02.004. Epub 2014 Feb 15.
Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs. The members of some of the multigene families exhibit unusually extensive patterns of divergence and the individual family members demonstrate marked variation in interspecific comparisons. As a group, the gene families reveal striking differences in domain type and content, mechanisms of intracellular signaling, basic structural features, haplotype and allelic variation and ligand binding. The potential functional roles of these innate immune receptors, their relationships to immune genes in higher vertebrate species and the basis for their adaptive evolution are of broad interest. Ongoing investigations are expected to provide new insight into alternative mechanisms of immunity.
在硬骨鱼中已鉴定出五个编码由免疫球蛋白结构域组成的先天型免疫受体的大型多基因家族，其中四个没有明确的哺乳动物直系同源物。一些多基因家族的成员表现出异常广泛的差异模式，并且在种间比较中各个家族成员表现出显著差异。作为一个整体，这些基因家族在结构域类型和含量、细胞内信号传导机制、基本结构特征、单倍型和等位基因变异以及配体结合方面显示出显著差异。这些先天免疫受体的潜在功能作用、它们与高等脊椎动物物种免疫基因的关系以及它们适应性进化的基础具有广泛的研究意义。正在进行的研究有望为免疫的替代机制提供新的见解。
