Morris A G
Department of Biological Sciences, University of Warwick, Coventry, U.K.
Immunol Suppl. 1988;1:43-5.
Interferon (IFN)-alpha and -beta are produced by virus-infected cells; IFN-gamma is produced as a primary response of T lymphocytes to mitogenic stimulation, IFN-gamma gene activation being brought about by changes in Ca2+ and phosphatidyl inositol metabolism. IFNs act by binding to cell surface receptors and triggering activation of IFN-responsive genes, probably via specific base sequences located in the 5' non-coding region of such genes, resulting in changes in cell function. Important genes activated in this way are the MHC antigen genes; class I induced by all IFNs, class II by IFN-gamma only. This MHC activation may have important consequences for lymphocyte function.
干扰素（IFN）-α和-β由病毒感染的细胞产生；IFN-γ作为T淋巴细胞对促有丝分裂刺激的主要反应产物而产生，IFN-γ基因的激活是由Ca2+和磷脂酰肌醇代谢的变化引起的。干扰素通过与细胞表面受体结合并可能经由位于此类基因5'非编码区的特定碱基序列触发IFN反应性基因的激活，从而导致细胞功能的改变。以这种方式被激活的重要基因是MHC抗原基因；I类由所有干扰素诱导，II类仅由IFN-γ诱导。这种MHC激活可能对淋巴细胞功能产生重要影响。
