Stewart C J, Farquharson M A, McNicol A M, Foulis A K
University Department of Pathology, Glasgow Royal Infirmary.
J Clin Pathol. 1990 Mar;43(3):230-4. doi: 10.1136/jcp.43.3.230.
Immunocytochemical staining for alpha-interferon was carried out on cervical biopsy specimens showing non-condylomatous koilocytic atypia (n = 12) and cervical intraepithelial neoplasia (n = 18), both of which are associated with human papilloma virus (HPV) infection. Normal cervical tissue obtained from hysterectomy specimens was also assessed. Koilocytes were not immunoreactive for alpha interferon and keratinocyte staining was observed in only four cases of intraepithelial neoplasia. HPV infection alone does not therefore seem to induce the production of alpha interferon in cervical squamous epithelium. There was variable but, in some cases, prominent staining of cells in the stromal inflammatory infiltrate as well as intraepithelial cells which had morphological and immunocytochemical characteristics of Langerhans' cells. Alpha interferon immunoreactivity in Langerhans' cells is in keeping with derivation from the mononuclear phagocyte system and may be important in the host response to HPV infection.
对显示非湿疣性挖空细胞异型性的宫颈活检标本（n = 12）和宫颈上皮内瘤变（n = 18）进行了α干扰素免疫细胞化学染色，这两种情况均与人乳头瘤病毒（HPV）感染相关。还评估了从子宫切除标本中获得的正常宫颈组织。挖空细胞对α干扰素无免疫反应，仅在4例上皮内瘤变中观察到角质形成细胞染色。因此，单纯HPV感染似乎不会诱导宫颈鳞状上皮产生α干扰素。基质炎性浸润中的细胞以及具有朗格汉斯细胞形态和免疫细胞化学特征的上皮内细胞存在不同程度但在某些情况下明显的染色。朗格汉斯细胞中的α干扰素免疫反应性与单核吞噬细胞系统的起源一致，可能在宿主对HPV感染的反应中起重要作用。
