持续性多克隆B细胞淋巴细胞增多症：具有独特免疫表型的广泛增殖的CD27⁺IgM⁺IgD⁺记忆B细胞。 - Suppr

Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype.

作者信息

Berkowska M A, Grosserichter-Wagener C, Adriaansen H J, de Ridder D, Mirani-Oostdijk K P, Agteresch H J, Böttcher S, Orfao A, van Dongen J J M, van Zelm M C

机构信息

1] Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands [2].

Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

出版信息

Leukemia. 2014 Jul;28(7):1560-4. doi: 10.1038/leu.2014.77. Epub 2014 Feb 19.

DOI:10.1038/leu.2014.77

PMID:24549258

Abstract

摘要

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Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype.持续性多克隆B细胞淋巴细胞增多症：具有独特免疫表型的广泛增殖的CD27⁺IgM⁺IgD⁺记忆B细胞。

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Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.表达CD27细胞表面抗原的人免疫球蛋白（Ig）M+IgD+外周血B细胞携带体细胞突变的可变区基因：CD27作为体细胞突变（记忆）B细胞的通用标志物。

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Persistent polyclonal B-cell lymphocytosis is an expansion of functional IgD(+)CD27(+) memory B cells.持续性多克隆B细胞淋巴细胞增多症是功能性IgD(+)CD27(+)记忆B细胞的扩增。

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Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype.

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