Department of Obstetrics and Gynecology and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona Biomedical Research Park, Barcelona, Spain.
Nat Rev Immunol. 2020 Jul;20(7):427-441. doi: 10.1038/s41577-019-0261-1. Epub 2020 Feb 3.
Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA on mucosal commensal bacteria. In the gut, IgA contributes to the establishment of a mutualistic host-microbiota relationship that is required to maintain homeostasis and prevent disease. This Review discusses how mucosal IgA responses occur in an increasingly complex humoral defence network that also encompasses IgM, IgG and IgD. Aside from integrating the protective functions of IgA, these hitherto neglected mucosal antibodies may strengthen the communication between mucosal and systemic immune compartments.
黏膜表面的体液免疫反应历来集中在 IgA 上。越来越多的证据强调了 IgA 诱导途径的复杂性以及 IgA 对黏膜共生细菌的功能影响。在肠道中，IgA 有助于建立一种共生的宿主-微生物关系，这是维持体内平衡和预防疾病所必需的。本综述讨论了黏膜 IgA 反应是如何在一个日益复杂的体液防御网络中发生的，该网络还包括 IgM、IgG 和 IgD。除了整合 IgA 的保护功能外，这些迄今为止被忽视的黏膜抗体还可能加强黏膜和系统免疫区室之间的交流。
