King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi ArabiadBharathiar University, Research and Development Centre, Coimbatore 641046, India.
King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi Arabia.
J Biomed Opt. 2014 Feb;19(2):027008. doi: 10.1117/1.JBO.19.2.027008.
Thalassemia (Thal), sickle cell anemia, and iron deficiency anemia (IDA) are the most common blood disorders in many parts of the world, particularly in developing countries like India and Bangladesh. The well-established diagnostic procedure for them is the complete blood count (CBC); however, there is substantial confusion in discrimination between Thal and IDA blood samples based on such CBC. We propose a new spectral technique for reliable classification between the above two anemias. This is based on the identification and quantification of a certain set of fluorescent metabolites found in the blood samples of patients of Thal and IDA.
地中海贫血症（Thal）、镰状细胞贫血症和缺铁性贫血症（IDA）是世界上许多地区，特别是印度和孟加拉国等发展中国家最常见的血液疾病。它们的既定诊断程序是全血细胞计数（CBC）；然而，根据这种 CBC 在 Thal 和 IDA 血液样本之间进行区分存在很大的混淆。我们提出了一种新的光谱技术，用于可靠地区分上述两种贫血症。这是基于鉴定和量化在 Thal 和 IDA 患者的血液样本中发现的一组特定荧光代谢物。
