多形性腺瘤癌变（未分化型和腺癌型）中p16的免疫组化表达
Immunohistochemical expression of p16 in Carcinoma Ex-pleomorphic Adenoma (undifferentiated and Adenocarcinoma Types).
作者信息
Tarakji Bassel, Altamimi Mohammed Alsakran, Baroudi Kusai, Nassain Mohammad Z, Alenzi Faris Q
机构信息
Faculty, Head of Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
出版信息
J Clin Diagn Res. 2013 Dec;7(12):3054-6. doi: 10.7860/JCDR/2013/7380.3851. Epub 2013 Dec 15.
OBJECTIVE
This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas.
STUDY DESIGN
A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined.
RESULTS
The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining.
CONCLUSION
This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
目的
本研究旨在描述多形性腺瘤癌变中p16免疫组化表达的改变。
研究设计
选取27例多形性腺瘤癌变病例进行检查。
结果
结果显示，27例中有23例（85%）非肿瘤导管细胞中的p16表达为强阳性核染色，3例（11.1%）为中度染色，1例（3.7%）为弱阳性染色。27例中有22例（81.4%）多形性腺瘤癌变中的p16表达为阴性核染色，5例（18.5%）为中度染色。
结论
本研究表明，在多形性腺瘤癌变中检测到p16表达改变。p16在多形性腺瘤癌变发展中起作用。
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