Halimi Mohammad, Asghari S Mohsen, Sariri Reyhaneh, Moslemi Dariush, Parsian Hadi
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
Department of Radiation oncology, Babol University of Medical Sciences, Babol, Iran.
Int J Mol Cell Med. 2012 Fall;1(4):178-84.
MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that microRNA-mediated gene regulation interferes with radio-related pathways in ionizing radiation. Here, we review the recent discoveries about miRNAs in cellular response to IR. Thoroughly understanding the mechanism of miRNAs in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment.
微小RNA（miRNA）是一类小的非编码RNA分子，它们在转录后水平调节基因表达。它们在多种细胞途径中发挥关键作用。电离辐射（IR）是癌症患者最重要的治疗方案之一，直接或间接影响细胞整合。最近发现，微小RNA介导的基因调控会干扰电离辐射中的辐射相关途径。在这里，我们综述了关于miRNA在细胞对IR反应中的最新发现。深入了解miRNA在辐射反应中的机制，将有可能设计新的策略来提高放射治疗效率，最终改善癌症治疗效果。
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