National Office of Cancer Prevention and Control, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Department of Pathology, Chinese Academy of Medical Sciences, Beijing 100021, China.
Biomed Environ Sci. 2014 Jan;27(1):3-9. doi: 10.3967/bes2014.010.
To characterize the histological and epidemiological features of male lung cancer patients in China.
The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31, was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies (RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth.
The RF of adenocarcinoma (ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma (SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study (Z=17.909, P<0.0001; Z=-6.117, P<0.0001). The RF of ADC increased from 28.72% in 2000-2004, 36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas.
The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced.
描述中国男性肺癌患者的组织学和流行病学特征。
收集中国医学科学院肿瘤医院 2000 年 1 月 1 日至 2012 年 12 月 31 日期间男性肺癌患者的人口统计学和组织学信息。根据诊断年份和出生年份，估计主要组织学亚型的相对频率（RF）并进行比较。
在纳入本研究的 15427 例男性肺癌患者中，腺癌（ADC）的 RF 从 2000 年的 21.96%增加到 2012 年的 43.36%，而鳞状细胞癌（SCC）的 RF 从 39.11%下降至 32.23%（Z=17.909，P<0.0001；Z=-6.117，P<0.0001）。出生于 1960 年后的患者中，ADC 的 RF 从 2000-2004 年的 28.72%、2005-2008 年的 36.88%上升至 2009-2012 年的 48.61%。2007-2012 年，所有调查地区年龄调整后的 ADC RF 持续增加。
男性肺癌患者中 ADC 的 RF 增加，强调需要进一步研究这些肿瘤的病因。应执行无烟政策，而不是改进烟草产品。
Zotero 插件