Sadowska-Wróblewska M, Wróblewska-Graff T, Weryńska-Przybylska J, Rell-Bakalarska M, Kurdybacha J
Institute of Rheumatology, Warsaw, Poland.
Z Rheumatol. 1988 Mar-Apr;47(2):113-6.
The etiology of rheumatoid arthritis is unknown. Virus infection is one of alleged factors initiating the disease process. In view of this, the authors undertook a trial of administration of an antiviral and immunostimulating preparation - isoprinosine, given in the early phase of the disease prior to the development of erosions. Isoprinosine was given to ten seropositive cases of rheumatoid arthritis (two males, eight females) aged 34-61 years, with disease duration from 6 months to 5 years treated previously only with non-steroidal anti-inflammatory drugs. Isoprinosine was administered for 4 weeks (2 weeks of 3.0 g daily and 2 weeks of 1.5 g daily). After the treatment, a statistically significant reduction was observed in the number of joints painful on pressure, the number of swollen joints, and the duration of morning stiffness. The grip strength of the left hand was increased. The ESR and serum uric acid level were not changed significantly. The titre of Waaler-Rose reaction in four patients was decreased, in two it was increased, and in four it remained unchanged. No side effects were observed during the treatment. In the light of these observations it seems worthwhile to continue further studies on the action of isoprinosine in early rheumatoid arthritis.
类风湿关节炎的病因尚不清楚。病毒感染是引发该病进程的所谓因素之一。鉴于此，作者进行了一项试验，在疾病早期、侵蚀性病变出现之前给予一种抗病毒和免疫刺激制剂——异丙肌苷。10例血清学阳性的类风湿关节炎患者（2例男性，8例女性），年龄34至61岁，病程6个月至5年，此前仅用非甾体抗炎药治疗，给予异丙肌苷。异丙肌苷给药4周（2周每日3.0 g，2周每日1.5 g）。治疗后，压痛关节数、肿胀关节数及晨僵持续时间均有统计学意义的减少。左手握力增加。血沉和血清尿酸水平无明显变化。4例患者的瓦勒 - 罗斯反应滴度降低，2例升高，4例不变。治疗期间未观察到副作用。鉴于这些观察结果，继续进一步研究异丙肌苷在早期类风湿关节炎中的作用似乎是值得的。
