Bouvier M, Bonvoisin B, Lejeune E, Sidot C, Touraine J L, Touraine F
Rev Rhum Mal Osteoartic. 1983 Oct;50(10):653-7.
Twenty patients with classical or proved rheumatoid arthritis were treated with Isoprinosine. 13 patients received a dose of 25 mg/kg/day and 7 received a dose of 50 mg/kg/day, continuously for 2 months and then discontinuously, 5 days every fortnight. The series being treated with 25 mg/kg/day (7 patients) have received treatment for 12 months. No side effects have been observed; the only reason for ceasing treatment was its ineffectiveness (after at least 3 months of administration). The dosage of the associated anti-inflammatory drugs did not need to be increased, but neither was it decreased. The authors conclude that Isoprinosine is largely ineffective clinically, on laboratory tests and in terms of immunology, at least with the therapeutic protocols tested here.
20例典型或确诊的类风湿性关节炎患者接受了异丙肌苷治疗。13例患者接受25mg/kg/天的剂量，7例接受50mg/kg/天的剂量，持续治疗2个月，然后间断治疗，每两周停药5天。接受25mg/kg/天治疗的7例患者已接受了12个月的治疗。未观察到副作用；停止治疗的唯一原因是治疗无效（至少给药3个月后）。相关抗炎药物的剂量无需增加，但也未减少。作者得出结论，至少就此处测试的治疗方案而言，异丙肌苷在临床、实验室检查及免疫学方面基本无效。
