Martinelli Sara, Rigolin Gian Matteo, Leo Genesio, Gafà Roberta, Lista Enrico, Cibien Francesca, Sofritti Olga, Daghia Giulia, Cavazzini Francesco, Cuneo Antonio
Section of Hematology, Azienda Ospedaliero-Universitaria S.Anna, Ferrara, Italy,
Int J Hematol. 2014;99(5):663-7. doi: 10.1007/s12185-014-1527-9. Epub 2014 Feb 20.
Sweet's syndrome is a rare condition with potentially disabling implications, characterized by painful skin lesions due to neutrophilic dermal infiltration and systemic inflammatory symptoms. A significant proportion of cases is malignancy associated. Hematologic neoplasms, particularly acute myeloid leukemia and myelodysplastic syndromes, are the most commonly associated malignant conditions. Here, we describe the first case of clinical remission of refractory Sweet's syndrome following hypomethylating therapy with azacytidine in a patient with myelodysplastic syndrome who concurrently obtained a complete hematologic response.
斯威特综合征是一种罕见疾病，可能产生致残影响，其特征为因中性粒细胞浸润皮肤而出现疼痛性皮损以及全身炎症症状。相当一部分病例与恶性肿瘤相关。血液系统肿瘤，尤其是急性髓系白血病和骨髓增生异常综合征，是最常伴发的恶性疾病。在此，我们报告首例骨髓增生异常综合征患者使用阿扎胞苷进行低甲基化治疗后难治性斯威特综合征临床缓解，同时该患者获得完全血液学缓解。
