Radionuclide Diagnostics Department, Medical Radiological Research Centre, Koroleva St. 4, Obninsk, 249036, Kaluga Region, Russia,
Biometals. 2014 Apr;27(2):333-48. doi: 10.1007/s10534-014-9716-9. Epub 2014 Feb 20.
The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0-30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work's results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0-30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.
使用仪器中子活化分析、电感耦合等离子体原子发射光谱和定量形态计量分析，研究了 50 名 0-30 岁个体完整前列腺中 18 种微量元素的质量分数随年龄的变化，以及一些组织学特征。青春期前，这些微量元素的质量分数（以每公斤湿组织毫克计）平均值±标准误差（M ± SEM）为：Al 28.5 ± 9.0、B 0.40 ± 0.11、Ba 1.48 ± 0.44、Br 10.5 ± 1.5、Ca 241 ± 30、Cl 3,203 ± 278、Cu 3.51 ± 0.89、Fe 33.7 ± 4.1、K 2,364 ± 145、Li 0.020 ± 0.004、Mg 153 ± 23、Mn 0.46 ± 0.06、Na 2,286 ± 130、P 1,391 ± 100、S 1,698 ± 132、Si 62 ± 11、Sr 0.38 ± 0.08 和 Zn 27.6 ± 2.3。在青春期和青春期后，当循环雄激素显著增加时，平均值为：Al 7.2 ± 1.4、B 0.21 ± 0.05、Ba 0.25 ± 0.06、Br 5.8 ± 1.0、Ca 433 ± 81、Cl 2,314 ± 201、Cu 1.77 ± 0.13、Fe 20.9 ± 1.6、K 2,585 ± 118、Li 0.0088 ± 0.0014、Mg 232 ± 27、Mn 0.34 ± 0.04、Na 1,875 ± 107、P 1,403 ± 98、S 1,673 ± 73、Si 22.2 ± 3.1、Sr 0.22 ± 0.03 和 Zn 93.3 ± 8.9。青春期前前列腺的基质、上皮和管腔的体积百分比（%）平均值（M ± SEM）分别为 73.4 ± 2.6、20.4 ± 1.7 和 4.45 ± 0.94，而青春期和青春期后分别为 46.5 ± 2.5、38.5 ± 1.9 和 14.9 ± 1.2。这项工作的结果证实，前列腺组织中的锌质量分数是雄激素依赖性的参数。首次证明，腺体腔是 Ca、Mg 和 Zn 积累的主要池，基质是 Al、B、Ba、Br、Cl、Cu、Fe、Mn、Na 和 Si 在正常前列腺中积累的主要池，年龄范围为 0-30 岁。结论是，由于腺体腔的体积反映了前列腺液的体积，因此 Ca、Mg 和 Zn 与前列腺液紧密结合。
