Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyeva Str. 4, Obninsk, 249036, Kaluga Region, Russia,
Biol Trace Elem Res. 2013 Dec;156(1-3):357-66. doi: 10.1007/s12011-013-9826-1. Epub 2013 Sep 26.
The effect of age on the mass fraction of 19 chemical elements in the intact prostate of 50 apparently healthy 0-30-year-old males was investigated by neutron activation analysis with high-resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry. Mean values (M ± standard error of the mean) for mass fraction (in milligrams per kilogram, on dry weight basis) of chemical elements were as follows: Al, 77 ± 17; B, 1.31 ± 0.29; Ba, 4.0 ± 1.2; Br, 37.7 ± 4.3; Ca, 1,536 ± 189; Cl, 13,414 ± 949; Cu, 12.3 ± 2.1; Fe, 132 ± 11; K, 11,547 ± 468; Li, 0.064 ± 0.009; Mg, 922 ± 89; Mn, 1.88 ± 0.16; Na, 9,834 ± 411; P, 6,741 ± 335; S, 8,034 ± 251; Si, 199 ± 34; Sr, 1.40 ± 0.19; and Zn, 277 ± 33. The upper limit of mean mass fraction of V was ≤0.24. This work revealed that there is significant tendency for the mass fractions of Ca, K, Mg, and Zn in the prostate tissue of healthy individuals to increase with age from the time of birth up to 30 years. It means that Ca, K, Mg, and Zn mass fractions in prostate tissue are the androgen-dependent parameters. Our finding of a positive correlation between the prostatic Zn and Ca, K, Mg, P, and S mass fractions indicates that there is a special relationship of Zn with some main electrolytes (Ca, K, and Mg) and with P- and S-containing compounds in the prostate. It was shown also that high levels of Al, B, Ba, Br, Cl, Li, Na, and Sr mass fraction in prostate tissue do not indicate a direct involvement of these elements in the reproductive function of the prostate.
应用高通量放射性核素的高分辨率光谱仪和电感耦合等离子体原子发射光谱法，对 50 名 0-30 岁健康男性完整前列腺中 19 种化学元素的质量分数与年龄的关系进行了研究。化学元素的质量分数（以毫克/千克为单位，基于干重）的平均值（M ± 平均值的标准误差）如下：Al，77 ± 17；B，1.31 ± 0.29；Ba，4.0 ± 1.2；Br，37.7 ± 4.3；Ca，1536 ± 189；Cl，13414 ± 949；Cu，12.3 ± 2.1；Fe，132 ± 11；K，11547 ± 468；Li，0.064 ± 0.009；Mg，922 ± 89；Mn，1.88 ± 0.16；Na，9834 ± 411；P，6741 ± 335；S，8034 ± 251；Si，199 ± 34；Sr，1.40 ± 0.19；Zn，277 ± 33。V 的平均质量分数上限≤0.24。本研究表明，健康个体前列腺组织中的 Ca、K、Mg 和 Zn 质量分数自出生至 30 岁有随年龄显著升高的趋势。这意味着前列腺组织中 Ca、K、Mg 和 Zn 的质量分数是雄激素依赖性参数。我们发现前列腺中 Zn 与 Ca、K、Mg、P 和 S 质量分数之间存在正相关，这表明 Zn 与前列腺中的一些主要电解质（Ca、K 和 Mg）和含 P、S 的化合物之间存在特殊关系。还表明，前列腺组织中高浓度的 Al、B、Ba、Br、Cl、Li、Na 和 Sr 质量分数并不表明这些元素直接参与前列腺的生殖功能。
