Center for integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185 (USA).
Angew Chem Int Ed Engl. 2014 Mar 24;53(13):3372-6. doi: 10.1002/anie.201309433. Epub 2014 Feb 19.
Large (200 nm) poly(ethylene oxide)-b-poly(butadiene) polymer vesicles fuse into giant (>1 μm) vesicles with mild agitation in dilute aqueous NaCl solutions. This unusual effect is attributed to the salt-induced contraction of the poly(ethylene oxide) corona, reducing steric resistance between vesicles and, with agitation, increasing the probability of contact between the hydrophobic cores of adjacent membranes. In addition, NaCl and agitation facilitated the creation of giant hybrid vesicles from much smaller homogeneous polymersomes and liposomes. Whereas lipid vesicles do not readily fuse with each other under the same circumstances, they did fuse with polymersomes to produce hybrid polymer/lipid vesicles.
在稀盐水中，大（200nm）的聚（氧化乙烯）-b-聚（丁二烯）聚合物囊泡在温和搅拌下融合成巨大（>1μm）的囊泡。这种不寻常的效应归因于盐诱导的聚（氧化乙烯）冠收缩，降低了囊泡之间的空间位阻，并且在搅拌下增加了相邻膜的疏水性核心之间接触的可能性。此外，NaCl 和搅拌促进了由小得多的均相聚合物囊泡和脂质体形成巨大的杂化囊泡。尽管在相同条件下脂质体不易彼此融合，但它们确实与聚合物囊泡融合形成了杂化聚合物/脂质体囊泡。
