Courneya Kerry S, Segal Roanne J, Mackey John R, Gelmon Karen, Friedenreich Christine M, Yasui Yutaka, Reid Robert D, Jespersen Diana, Cook Diane, Proulx Carolyn, Trinh Linda, Dolan Lianne B, Wooding Evyanne, Forbes Cynthia C, McKenzie Donald C
Faculty of Physical Education and Recreation, University of Alberta, E-488 Van Vliet Center, Edmonton, AB, T6G 2H9, Canada,
Breast Cancer Res Treat. 2014 Apr;144(2):361-9. doi: 10.1007/s10549-014-2883-0. Epub 2014 Feb 20.
To examine the effects of different doses and types of exercise on sleep quality in breast cancer patients receiving chemotherapy. A multicenter trial in Canada randomized 301 breast cancer patients between 2008 and 2011 to thrice weekly, supervised exercise during chemotherapy consisting of either a standard dose of 25-30 min of aerobic exercise (STAN; n = 96), a higher dose of 50-60 min of aerobic exercise (HIGH; n = 101), or a combined dose of 50-60 min of aerobic and resistance exercise (COMB; n = 104). The secondary sleep outcomes in the trial were assessed by the Pittsburgh Sleep Quality Index (PSQI) at baseline, twice during chemotherapy, and postchemotherapy. We analyzed the global PSQI and the component scores. Repeated measures analyses of variance indicated that the HIGH group was statistically superior to the STAN group for global sleep quality (mean group difference = -0.90; 95 % CI -0.05 to -1.76; p = 0.039) as well as subjective sleep quality (p = 0.028) and sleep latency (p = 0.049). The COMB group was borderline statistically superior to the STAN group for global sleep quality (mean group difference = -0.76; 95 % CI +0.11 to -1.62; p = 0.085) as well as sleep duration (p = 0.051); and statistically superior for sleep efficiency (p = 0.040), and percentage of poor sleepers (p = 0.045). Compared to a standard volume of aerobic exercise, higher volumes of both aerobic and combined exercise improved some aspects of sleep quality during breast cancer chemotherapy. Exercise may be an attractive option to manage sleep dysfunction in cancer patients during chemotherapy.
为研究不同剂量和类型的运动对接受化疗的乳腺癌患者睡眠质量的影响。加拿大的一项多中心试验在2008年至2011年间将301名乳腺癌患者随机分为三组，在化疗期间每周接受三次有监督的运动，其中一组为标准剂量的25 - 30分钟有氧运动（STAN组；n = 96），一组为更高剂量的50 - 60分钟有氧运动（HIGH组；n = 101），另一组为50 - 60分钟有氧运动与抗阻运动相结合的运动（COMB组；n = 104）。该试验中的次要睡眠结局通过匹兹堡睡眠质量指数（PSQI）在基线、化疗期间两次以及化疗后进行评估。我们分析了PSQI总分及各成分得分。重复测量方差分析表明，HIGH组在总体睡眠质量（组间平均差异=-0.90；95%可信区间-0.05至-1.76；p = 0.039）、主观睡眠质量（p = 0.028）和睡眠潜伏期（p = 0.049）方面在统计学上优于STAN组。COMB组在总体睡眠质量（组间平均差异=-0.76；95%可信区间+0.11至-1.62；p = 0.085）以及睡眠时间（p = 0.051）方面在统计学上接近优于STAN组；在睡眠效率（p = 0.040）和睡眠不佳者比例（p = 0.045）方面在统计学上优于STAN组。与标准量的有氧运动相比，更高量的有氧运动以及联合运动改善了乳腺癌化疗期间睡眠质量的某些方面。运动可能是管理癌症患者化疗期间睡眠功能障碍的一个有吸引力的选择。
