Gashi Njazi, Islami Pëllumb, Mustafa Lirim, Maloku Halit, Veseli Arta, Islami Hilmi
Department of Pediatric, Faculty of Medicine. University of Prishtina. Clinical Centre, Prishtina, Kosova.
Smartmed, St.Rexhep Krasniqi, EXDC, Prishtina, Kosova.
Acta Inform Med. 2013 Dec;21(4):266-9. doi: 10.5455/aim.2013.21.266-269. Epub 2013 Dec 4.
In this work, role of the adrenergic nerve system (alpha1 and beta2) in adjustment of the bronchomotor tonus in healthy people was researched.
Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines - Asema.
Results gained shows that following the blockade of beta-2 adrenergic receptor with Propranolol (20 mg-aerosol), stimulation of alpha adrenergic receptor with Oxedrine (120 mg-aerosol) and blockage of these receptors with Tolazoline (20 mg-aerosol), does not change significantly the bronchomotor tonus of the tracheobronchial tree (p > 0.1). Meanwhile, stimulation of the beta-2 adrenergic receptor with Hexoprenaline (2 inh × 0.2 mg) is associated with a significant increase of the peripheral resistance of the airways (p < 0.01).
This suggests that the activity of the alpha1-adrenergic receptor, unlike the activity of the beta2-adrenergic receptor in the healthy people smooth musculature, is not significant and as such is insufficient to oppose to the tonic activities of the cholinergic system.
在本研究中,探究了肾上腺素能神经系统(α1和β2)在健康人支气管运动张力调节中的作用。
通过体容积描记法测定肺功能参数。记录气道阻力(Raw)和比气道传导率(sGaw),并计算比气道阻力(SRaw)。使用标准雾化器(Asema)进行雾化。
结果表明,用普萘洛尔(20mg雾化剂)阻断β2肾上腺素能受体、用麻黄碱(120mg雾化剂)刺激α肾上腺素能受体以及用妥拉唑啉(20mg雾化剂)阻断这些受体后,气管支气管树的支气管运动张力没有显著变化(p>0.1)。同时,用海索那林(2次吸入×0.2mg)刺激β2肾上腺素能受体与气道外周阻力的显著增加有关(p<0.01)。
这表明,与健康人平滑肌中β2肾上腺素能受体的活性不同,α1肾上腺素能受体的活性不显著,因此不足以对抗胆碱能系统的紧张性活动。