Lindgren B R, Ekström T, Andersson R G
Am Rev Respir Dis. 1986 Aug;134(2):266-9. doi: 10.1164/arrd.1986.134.2.266.
To study the effect of inhaled clonidine on broncho-obstruction in asthmatics, 10 patients with extrinsic asthma were broncho-provoked twice with an allergen that had been shown to give positive skin prick test results. Before the provocations, saline or clonidine (75 micrograms) was inhaled via a DeVilbiss no. 40 nebulizer. Clonidine slightly improved the basal respiratory function without significantly influencing the blood pressure. There was a reduction in the allergen-evoked broncho-obstruction by 42 to 65% after pretreatment with clonidine. The eosinophilic leukocytes in peripheral blood had a slight tendency to leave the circulatory system during the provocation preceded by the clonidine treatment. These data add further evidence to the finding that clonidine may be of interest in the treatment of broncho-obstructive diseases.
为研究吸入可乐定对哮喘患者支气管阻塞的影响，对10例过敏性哮喘患者使用已证实皮肤点刺试验呈阳性的变应原进行了两次支气管激发试验。在激发试验前，通过德维比斯40号雾化器吸入生理盐水或可乐定（75微克）。可乐定可轻微改善基础呼吸功能，且对血压无显著影响。可乐定预处理后，变应原诱发的支气管阻塞减少了42%至65%。在可乐定治疗后的激发试验期间，外周血中的嗜酸性白细胞有轻微离开循环系统的倾向。这些数据进一步证明了可乐定在支气管阻塞性疾病治疗中可能具有应用价值。
