Sabbah A, Lebricon T, Penn P, Vassal V, Heulin M G
Laboratoires Pharmacia, Angers.
Allerg Immunol (Paris). 1987 Sep;19(7):268-81.
Measurement of the titre of specific IgG4 by the ELISA method may provide objective assistance to the control of specific immunotherapy (IS) to hymenoptera venom and grass pollens. A marked increase of the specific IgG4 titre in the first 3 months of IS or a titre already raised before the start of IS correlated with poor clinical results. Specific IgG4 can not be considered to be a diagnostic indicator in food allergy since we have frequently found this type of antibody in control subjects. Specific IgG4 in food allergy expresses a mucosal marker rather than a pathological reaction.
采用酶联免疫吸附测定（ELISA）法测量特异性IgG4的滴度，可为膜翅目毒液和草花粉特异性免疫疗法（IS）的控制提供客观帮助。在免疫疗法开始的前3个月内特异性IgG4滴度显著升高，或在免疫疗法开始前滴度就已升高，均与临床效果不佳相关。在食物过敏中，特异性IgG4不能被视为诊断指标，因为我们经常在对照受试者中发现这类抗体。食物过敏中的特异性IgG4表达的是一种黏膜标志物，而非病理反应。
