Teh B S, Seow W K, Chalmers A H, Playford S, Ioannoni B, Thong Y H
Department of Child Health, University of Queensland, South Brisbane, Australia.
Int Arch Allergy Appl Immunol. 1988;86(2):220-4. doi: 10.1159/000234575.
The plant alkaloid tetrandrine was shown to have significant inhibitory effects on receptor-ligand-mediated histamine release from rat mast cells at concentrations similar to or lower than that observed with theophylline and sodium cromoglycate. Inhibition of histamine release did not occur when non-specific stimulants such as aspirin, A23187 or adenosine triphosphate were used. Inhibition of ovalbumin-IgE and concanavalin A-mediated histamine release was reversible by washing the cells, showing that tetrandrine does not bind tightly to the cell membrane or cytoplasmic components. These results, taken together with previous reports of its anti-phagocytic, anti-oxidant and immunosuppressive properties, suggest that tetrandrine may be a broad spectrum non-steroidal drug of potential value in the treatment of allergic diseases.
植物生物碱粉防己碱在浓度与茶碱和色甘酸钠相似或更低时，对大鼠肥大细胞中受体 - 配体介导的组胺释放具有显著抑制作用。当使用阿司匹林、A23187或三磷酸腺苷等非特异性刺激剂时，组胺释放并未受到抑制。通过洗涤细胞，粉防己碱对卵清蛋白 - IgE和伴刀豆球蛋白A介导的组胺释放的抑制作用是可逆的，这表明粉防己碱不会紧密结合到细胞膜或细胞质成分上。这些结果，连同其先前报道的抗吞噬、抗氧化和免疫抑制特性，表明粉防己碱可能是一种在过敏性疾病治疗中具有潜在价值的广谱非甾体药物。
