环孢素A对人白细胞和大鼠肥大细胞组胺释放的抑制作用。
Inhibitory effect of cyclosporin A on histamine release from human leukocytes and rat mast cells.
作者信息
Pedersen C, Permin H, Stahl Skov P, Norn S, Svenson M, Mosbech H, Bendtzen K
出版信息
Allergy. 1985 Feb;40(2):103-7. doi: 10.1111/j.1398-9995.1985.tb02668.x.
The influence of cyclosporin A (CyA) on human basophil histamine release induced in vitro by specific antigen, anti-IgE, calcium ionophore A23187, or concanavalin A (Con A) was studied. CyA inhibited the release induced by these four stimulators. It is suggested that the drug acts directly on the target cell, since similar effect was obtained with isolated peritoneal rat mast cells. The basophil histamine release was not changed by a non-immunosuppressive cyclosporin derivate.
研究了环孢素A（CyA）对特异性抗原、抗IgE、钙离子载体A23187或伴刀豆球蛋白A（Con A）体外诱导的人嗜碱性粒细胞组胺释放的影响。CyA抑制了这四种刺激物诱导的释放。由于在分离的大鼠腹膜肥大细胞中也获得了类似的效果，提示该药物直接作用于靶细胞。一种非免疫抑制性环孢素衍生物不会改变嗜碱性粒细胞组胺释放。
Zotero 插件