Seow W K, Ferrante A, Goh D B, Chalmers A H, Li S Y, Thong Y H
Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Int Arch Allergy Appl Immunol. 1988;85(4):410-5. doi: 10.1159/000234543.
Tetrandrine is an extract of the creeper Stephania tetrandra used in traditional Chinese medicine for the treatment of rheumatic diseases. It has recently been shown to retard and even reverse the lesions of silicosis in humans and rats. Data presented in this report indicate that tetrandrine has potent immunosuppressive properties. Mitogen-induced lymphoproliferative responses were markedly reduced even when tetrandrine was added after the initiation of cultures. In vitro antibody synthesis by B cells was also suppressed by tetrandrine, as was the natural killer cell-mediated lysis of K562 cells. It does not interfere with receptor-ligand binding, but does affect the inositol triphosphate second messenger system. These effects of tetrandrine were observed at nontoxic concentrations as shown by lymphocyte viability studies. These results indicate that tetrandrine possesses potent immunosuppressive properties, and may warrant further study in animal models of chronic inflammatory conditions, autoimmune diseases and transplant rejection.
粉防己碱是防己科植物粉防己的提取物，在传统中药中用于治疗风湿性疾病。最近的研究表明，它能延缓甚至逆转人类和大鼠矽肺的病变。本报告中的数据表明，粉防己碱具有强大的免疫抑制特性。即使在培养开始后添加粉防己碱，丝裂原诱导的淋巴细胞增殖反应也会显著降低。粉防己碱还抑制B细胞的体外抗体合成，以及自然杀伤细胞介导的K562细胞裂解。它不干扰受体 - 配体结合，但会影响肌醇三磷酸第二信使系统。淋巴细胞活力研究表明，在无毒浓度下可观察到粉防己碱的这些作用。这些结果表明，粉防己碱具有强大的免疫抑制特性，可能值得在慢性炎症、自身免疫性疾病和移植排斥反应的动物模型中进行进一步研究。
