Mendlovic S, Shoenfeld Y, Bakimer R, Segal R, Dayan M, Mozes E
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
J Clin Immunol. 1988 May;8(3):178-87. doi: 10.1007/BF00917564.
The human monoclonal autoantibody 16/6 is a common anti-DNA idiotype found to have clinical relevance in patients with systemic lupus erythematosus (SLE). Therefore the ability of peripheral blood T cells of SLE patients and healthy controls to proliferate and to produce helper T-cell factors following stimulation with this idiotype was tested. It was found that T cells of 75% of healthy donors proliferated to the 16/6 idiotype, whereas only 22% of SLE patients responded to this idiotype by proliferation. On the other hand, the capability to produce T-cell helper factors specific to the 16/6 idiotype was found in a higher percentage of SLE patients (48%) as compared to healthy controls (31%). The low frequency of proliferative responses in SLE patients might be due either to the chronic exposure to the 16/6 idiotype or to the production of antiidiotype antibodies against the 16/6 idiotype, which interfere with the response to the latter stimulator.
人单克隆自身抗体16/6是一种常见的抗DNA独特型，已发现其在系统性红斑狼疮（SLE）患者中具有临床相关性。因此，测试了SLE患者和健康对照者外周血T细胞在用这种独特型刺激后增殖并产生辅助性T细胞因子的能力。结果发现，75%的健康供体的T细胞对16/6独特型发生增殖，而只有22%的SLE患者通过增殖对这种独特型作出反应。另一方面，与健康对照者（31%）相比，发现更高比例的SLE患者（48%）具有产生针对16/6独特型的T细胞辅助因子的能力。SLE患者增殖反应频率低可能是由于长期接触16/6独特型，或者是由于产生了针对16/6独特型的抗独特型抗体，从而干扰了对后一种刺激物的反应。
