Sours Chandler, Rosenberg Joseph, Kane Robert, Roys Steve, Zhuo Jiachen, Shanmuganathan Kathirkamanthan, Gullapalli Rao P
Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA,
Brain Imaging Behav. 2015 Jun;9(2):190-203. doi: 10.1007/s11682-014-9295-y.
This study investigates cognitive deficits and alterations in resting state functional connectivity in civilian mild traumatic brain injury (mTBI) participants with high and low symptoms. Forty-one mTBI participants completed a resting state fMRI scan and the Automated Neuropsychological Assessment Metrics (ANAM) during initial testing (<10 days of injury) and a 1 month follow up. Data were compared to 30 healthy control subjects. Results from the ANAM demonstrate that mTBI participants performed significantly worse than controls on the code substitution delayed subtest (p = 0.032). [corrected]. Among the mTBI patients, high symptom mTBI participants performed worse than those with low symptoms on the code substitution delayed (p = 0.017), code substitution (p = 0.012), repeated simple reaction time (p = 0.031), and weighted throughput score (p = 0.019). [corrected]. Imaging results reveal that during the initial visit, low symptom mTBI participants had reduced interhemispheric functional connectivity (IH-FC) within the lateral parietal lobe (p = 0.020); however, during follow up, high symptom mTBI participants showed reduced IH-FC compared to the control group within the dorsolateral prefrontal cortex (DLPFC) (p = 0.013). Reduced IH-FC within the DLPFC during the follow-up was associated with reduced cognitive performance. Together, these findings suggest that reduced rs-FC may contribute to the subtle cognitive deficits noted in high symptom mTBI participants compared to control subjects and low symptom mTBI participants.
本研究调查了具有高症状和低症状的 civilian 轻度创伤性脑损伤（mTBI）参与者的认知缺陷和静息态功能连接的改变。41 名 mTBI 参与者在初始测试（受伤后<10 天）和 1 个月随访期间完成了静息态功能磁共振成像扫描和自动神经心理评估指标（ANAM）。数据与 30 名健康对照受试者进行了比较。ANAM 的结果表明，mTBI 参与者在代码替换延迟子测试中的表现明显比对照组差（p = 0.032）。[已校正]。在 mTBI 患者中，高症状 mTBI 参与者在代码替换延迟（p = 0.017）、代码替换（p = 0.012）、重复简单反应时间（p = 0.031）和加权吞吐量得分（p = 0.019）方面比低症状参与者表现更差。[已校正]。成像结果显示，在初次就诊时，低症状 mTBI 参与者在外侧顶叶内的半球间功能连接（IH-FC）降低（p = 0.020）；然而，在随访期间，高症状 mTBI 参与者与对照组相比，在背外侧前额叶皮质（DLPFC）内的 IH-FC 降低（p = 0.013）。随访期间 DLPFC 内 IH-FC 的降低与认知表现的降低有关。总之，这些发现表明，与对照组和低症状 mTBI 参与者相比，静息态功能连接（rs-FC）降低可能导致高症状 mTBI 参与者出现细微的认知缺陷。
